| 中文名称: | YM-244769 dihydrochloride | ||||
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| 英文名称: | YM-244769 dihydrochloride | ||||
| 别名: | YM-244769 dihydrochloride YM-244769 dihydrochloride | ||||
| CAS No: | 1780390-65-9 | 分子式: | C26H24Cl2FN3O3 | 分子量: | 516.39 |
| CAS No: | 1780390-65-9 | ||||
| 分子式: | C26H24Cl2FN3O3 | ||||
| 分子量: | 516.39 | ||||
基本信息
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产品编号： |
Y10042 |
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产品名称： |
YM-244769 dihydrochloride |
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CAS: |
1780390-65-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
二年 |
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分子量： |
516.39 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种有效的钠钙交换体(Na+/Ca2+exchange;NCX)抑制剂，YM-244769dihydrochloride优先抑制NCX3(IC50=18nM)。YM-244769dihydrochloride具有神经和肾脏保护。 |
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靶点 |
Na+/Ca2+Exchanger |
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体外研究 |
YM-244769 preferentially inhibits intracellular Na+-dependent 45Ca2+uptake via NCX3 (IC50=18nM);the inhibition is 3.8-to 5.3-fold greater than for the uptake via NCX1 or NCX2,but it does not significantly affect extracellular Na+-dependent 45Ca2+efflux via NCX isoforms.YM-244769 (0.003-1μM) inhibits dose dependently the initial rates of 45Ca2+uptake into NCX1,NCX2,and NCX3 transfectants with IC50 values of 68±2.9,96±3.5,and 18±1.0nM,respectively,indicating that YM-244769 is approximately four to five times more selective to NCX3 than other isoforms.YM-244769 (0.3 or 1μM) efficiently suppresses the hypoxia/reoxygenation-induced cell damage in SH-SY5Y cells treated with NCX1 antisense (i.e.,SH-SY5Y cells primarily expressing NCX3) more than in those treated with NCX3 antisense (i.e.,SH-SY5Y cells primarily expressing NCX1). Cell Viability Assay |
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Cell Line: |
SH-SY5Y cells treated with NCX1 or NCX3 antisense |
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Concentration: |
0.3 and 1μM |
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Result: |
Hypoxia/reoxygenation-induced LDH release was significantly attenuated:reduction in cell damage was greater in cells treated with NCX3 antisense (by 61%) than in cells treated with NCX1 antisense (by 35%).0.3 or 1μM efficiently suppressed the hypoxia/reoxygenation-induced cell damage in SHSY5Y cells treated with NCX1 antisense more than in those treated with NCX3 antisense. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
