| 中文名称: | YQ128 | ||||
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| 英文名称: | YQ128 | ||||
| CAS No: | 2454246-18-3 | 分子式: | C27H29ClN2O4S2 | 分子量: | 545.11 |
| CAS No: | 2454246-18-3 | ||||
| 分子式: | C27H29ClN2O4S2 | ||||
| 分子量: | 545.11 | ||||
基本信息
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产品编号： |
Y10038 |
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产品名称： |
YQ128 |
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CAS: |
2454246-18-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
545.11 |
-20℃ |
1个月 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
100mg/mL (183.44mM) |
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Ethanol |
3mg/mL (5.5mM) |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.8345mL |
9.1725mL |
18.3449mL |
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5mM |
0.3669mL |
1.8345mL |
3.6690mL |
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10mM |
0.1834mL |
0.9172mL |
1.8345mL |
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50mM |
0.0367mL |
0.1834mL |
0.3669mL |
生物活性
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产品描述 |
一种有效的，选择性第二代NLRP3炎性体抑制剂。 |
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靶点 |
NLRP3 |
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0.30μM |
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体外研究 |
YQ128 (0.3-100µM;30 mins) dose dependently suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC50 of 1.59µM.YQ128 (20µM;2 hours) shows no significant toxic effects on hCMEC/D3 cells. Cell Viability Assay |
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Cell Line: |
Mouse peritoneal macrophages |
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Concentration: |
0.3,1.0,3.0,10,30,100µM |
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Incubation Time: |
30 mins |
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Result: |
Suppressed the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with an IC50 of 1.59µM. |
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体内研究 |
YQ128 (iv;20mg/kg) has an intermediate terminal plasma half-life (t1/2) of 6.6 hours after iv administration.YQ128 (oral;20mg/kg) shows delayed gastrointestinal absorption with a tmax and cmax of 12h and 73ng/mL,respectively.Oral bioavailability (Foral) is estimated as 10%.YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vdss) of 8.5L/kg and rapid total clearance (CLtot) of 41mL/min/kg.YQ128 (10mg/kg) has been shown to trigger IL-1β production in a NLRP3-dependent manner in C57BL/6 mice. |
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Animal Model: |
Sprague-Dawley rats (200-250g) |
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Dosage: |
20mg/kg (Pharmacokinetic Analysis) |
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Administration: |
Iv |
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Result: |
Had an intermediate terminal plasma half-life(t1/2)of 6.6 hours after iv administration. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
