| 中文名称: | VER-246608 | ||||
|---|---|---|---|---|---|
| 英文名称: | VER-246608 | ||||
| 别名: | N-(4-(2-氯-5-甲基嘧啶-4-基)苯基)-N-(4-((2,2-二氟乙酰氨基)甲基)苄基)-2,4-二羟基苯甲酰胺 N-(4-(2-Chloro-5-methylpyrimidin-4-yl)phenyl)-N-(4-((2,2-difluoroacetamido)methyl)benzyl)-2,4-dihydroxybenzamide | ||||
| CAS No: | 1684386-71-7 | 分子式: | C28H23ClF2N4O4 | 分子量: | 552.96 |
| CAS No: | 1684386-71-7 | ||||
| 分子式: | C28H23ClF2N4O4 | ||||
| 分子量: | 552.96 | ||||
一种有效的，ATP竞争性的丙酮酸脱氢酶激酶(PDK)抑制剂。
VER-246608 is a pan-inhibitor of pyruvate dehydrogenase kinase (PDHK; IC50s = 35, 84, 40, and 91 nM for PDHK1, -2, -3, and -4, respectively). It is selective for PDHKs over heat shock protein 90 (Hsp90; IC50 = >100 µM), as well as a panel of 97 kinases at 10 µM. VER-246608 (10 and 20 µM) decreases the production of L-lactate, a marker of glycolytic activity, in PC3 cells cultured in D-glucose- and L-glutamine-depleted media. It reduces the growth of, and induces cell cycle arrest at the G1 phase in, serum-starved PC3 cells when used at a concentration of 20 µM.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
