| 中文名称: | TDCPP 促销 | ||||
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| 英文名称: | Tris(1,3-dichloropropan-2-yl) phosphate | ||||
| 别名: | 1,3-二氯-2-丙醇磷酸酯 Tris(1,3-dichloro-2-propyl)phosphate;Phosphoric Acid Tris(1,3-dichloro-2-propyl) Ester | ||||
| CAS No: | 13674-87-8 | 分子式: | C9H15Cl6O4P | 分子量: | 430.89 |
| CAS No: | 13674-87-8 | ||||
| 分子式: | C9H15Cl6O4P | ||||
| 分子量: | 430.89 | ||||
| MDL: | MFCD00083121 | EINEC: | 237-159-2 | ||
| EINEC: | 237-159-2 | ||||
基本信息
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产品编号： |
T80007 |
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产品名称： |
Tris(1,3-dichloropropan-2-yl) phosphate |
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CAS: |
13674-87-8 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
430.89 |
-20℃ |
1个月 |
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化学名： |
Phosphoric acid tris(1,3-dichloro-2-propyl) ester |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.3207mL |
11.6036mL |
23.2072mL |
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5mM |
0.4641mL |
2.3207mL |
4.6414mL |
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10mM |
0.2321mL |
1.1604mL |
2.3207mL |
生物活性
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产品描述 |
TDCPP是三(2,3-二溴丙基)磷酸酯(Tris)的氯化类似物，它是在环境中检测到的最多的有机磷阻燃剂(OPFR)之一。 |
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靶点 |
Others |
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体外研究 |
Exposure to TDCPP does not significantly affect cell viability until at concentration >68μg/mL.HCECs show a 16% cell viability loss after exposing to 136μg/mL TDCPP.Moreover,TDCPP induces a sharp decrease in viable cells (87%) after exposing to ≥272μg/mL TDCPP.Based on cell viability,the LC50 value for TDCPP is 202μg/mL using a nonlinear regression.Compare to controls,TDCPP-exposed cells exhibit a concentration-dependent increase in apoptosis.Anti-apoptotic Bcl-2 protein expression is increased to 1.4 fold after exposing to 2μg/mL TDCPP,1.2-folds at 20μg/mL but dynamically decreased to 0.4 fold at 200μg/mL compare to control.The caspase-3 activity is increased to 2.1 folds of the control at 200μg/mL TDCPP.TDCPP inhibits cell growth at lower concentrations (IC50 of 27μM),while cell viability and toxicity are affected at higher concentrations (IC50 of 171μM and 168μM,respectively). |
推荐实验方法(仅供参考)
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激酶实验： |
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The cellular ATP contents are determined in HCECs grown in DMEM containing 0,2,20,or 200μg/mL TDCPP using a luciferase-based ATP assay kit according to the manufacturer's guideline.Briefly,after 24h exposure,HCECs are lysed with lysis buffer.Lysates are then centrifuged at 12,000g at 4℃ for 5 min.Then,100μL of supernatant is mixed with 100μL ATP detection working dilution.Luminance is examined by an fluorescence microplate reader. |
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细胞实验: |
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To examine the effects of TDCPP on cell viability,HCECs are planted into 96-well plate (100μL/well) at density of 1×105 cells/mL overnight.Then,the medium is changed into fresh medium containing 0.034,0.34,3.4,34,68,136,272,or 340μg/mL of TDCPP and solvent vehicle (0.1%,v/v) and incubated for 24h.Cell viability is detected using CCK-8 cell viability assay kit according to the manufacturer's instructions.After exposure, cellular morphology is observed and recorded by an inverted microscopy. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
