| 中文名称: | Teglarinad chloride | ||||
|---|---|---|---|---|---|
| 英文名称: | Teglarinad chloride | ||||
| 别名: | Teglarinad chloride GMX1777;EB-1627 | ||||
| CAS No: | 432037-57-5 | 分子式: | C30H43Cl2N5O8 | 分子量: | 672.6 |
| CAS No: | 432037-57-5 | ||||
| 分子式: | C30H43Cl2N5O8 | ||||
| 分子量: | 672.6 | ||||
一种烟酰胺磷酸核糖基转移酶抑制剂)的前药。在小鼠中表现出抗肿瘤活性可以归因于NAMPT的抑制。通过干扰DNA修复和抗血管生成，可以增强放射功效。
Teglarinad chloride, also known as GMX-1777 and EB1627, is a potent NAMPT inhibitor. GMX1777 is a water-soluble prodrug of the cyanoguanidine compound GMX1778 with potential antineoplastic activity. In vivo, apoptosis inducer GMX1777 is rapidly converted into GMX1778 through hydrolytic cleavage of a carbonate ester bond. Although the exact mechanism of action has yet to be fully elucidated, GMX1778 appears to antagonize nuclear factor-kappa B (NF-kB) transcription, resulting in the induction of tumor cell apoptosis.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
