| 中文名称: | TTT-28 | ||||
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| 英文名称: | TTT-28 | ||||
| 别名: | TTT-28 TTT-28 | ||||
| CAS No: | 1609138-51-3 | 分子式: | C31H31N3O6S | 分子量: | 573.66 |
| CAS No: | 1609138-51-3 | ||||
| 分子式: | C31H31N3O6S | ||||
| 分子量: | 573.66 | ||||
基本信息
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产品编号： |
T11028 |
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产品名称： |
TTT-28 |
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CAS: |
1609138-51-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
二年 |
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分子量： |
573.66 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种噻唑-缬氨酸肽模拟物，高效ABCB1(P-gp/MDR1)选择性抑制剂，低毒性。TTT-28通过选择性阻断ATP结合盒亚家族B成员1(ABCB1)的外排功能,逆转ABCB1介导的多药耐药性(MDR)。 |
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靶点 |
P-glycoprotein |
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体外研究 |
TTT-28 (0-100μM;72 hours) reverses ABCB1-mediated MDR in drug selected SW620/Ad300 cells and transfected HEK293/ABCB1 cells;the IC50s of TTT-28 in CCD-18Co,SW620 and SW620/Ad300 cells are 213.4±11.0μM,89.4±3.9μM and 92.0±5.0μM,respectively.TTT-28 (10μM;2 hours) raises the ABCB1-mediated MDR and increased the accumulation of [3H]-paclitaxel in ABCB1 overexpressing cells.TTT-28 (10μM;0-72 hours) does not interfer with the expression level and localization of ABCB1,it results from blocking the efflux function of ABCB1.TTT-28 (0-40μM;2 hours) interacts at the drug-substrate-binding site and actives the ATPase activity of ABCB1 in a concentration-dependent fashion. Cell Viability Assay |
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Cell Line: |
SW620 cells,SW620/Ad300 cells |
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Concentration: |
0.1μM,1μM,10μM,100μM |
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Incubation Time: |
72 hours |
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Result: |
Decreased the resistance fold of ABCB1 substrates (Paclitaxel, Doxorubicin, Vincristine) in SW620/Ad300 cells compared to SW620 cells. |
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体内研究 |
TTT-28 (deliver orally;30mg/kg;every 3 rd day;18 days) potentiates the anticancer activity of paclitaxel due to its inhibitory effect on the efflux function of ABCB1,it enhances the inhibitory effect of paclitaxel on the growth of SW620/Ad300 tumor and promoted apoptosis. |
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Animal Model: |
5-10 week Male athymic NCR (nu/nu) nude mice ABCB1 overexpressing tumor xenograft model with SW620/Ad300 cells |
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Dosage: |
30mg/kg |
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Administration: |
Deliver orally;every 3rd day;18 days |
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Result: |
Lead to higher intratumoral accumulation of paclitaxel in tumors. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
