曲金刚胺 - CAS:53783-83-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	曲金刚胺
英文名称:	Tromantadine
别名:	曲金刚胺 Tromantadine
CAS No:	53783-83-8	分子式:	C₁₆H₂₈N₂O₂	分子量:	280.41
CAS No:	53783-83-8
分子式:	C₁₆H₂₈N₂O₂
分子量:	280.41
EINEC:	258-770-0
EINEC:	258-770-0

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

T10636 曲金刚胺 ≥98% (psaitong)

相关产品

包装规格：

100mg 250mg 500mg in glass bottle

产品描述：

基本信息

产品编号：T10636
产品名称：Tromantadine
CAS:	53783-83-8	储存条件	粉末	-20℃	四年

分子式：	C16H28N2O2		溶于液体	-80℃	六个月
分子量	280.41			-20℃	一个月
化学名：	N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide
Solubility (25°C)	体外	DMSO
		Ethanol
		Water
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

生物活性

产品描述

一种Amantadine 衍生物，具有抗疱疹活性，可抑制单纯疱疹病毒1型 (HSV-1) 和 HSV-2 的复制。

靶点/IC₅₀

HSV-1

HSV-2

体外研究

Tromantadine inhibits herpes simplex virus type 1 (KOS strain)-induced cytopathic effect and virus replication with limited toxicity to the cells. Vero and HEp-2 cells tolerate up to 2mg of Tromantadine per 2x106 cells for 24-, 48-, or 96-h incubation periods with little change in cell morphology. Treatment of the cells with 10 to 50μg of Tromantadine reduces herpes simplex virus-induced cytopathic effect. Treatment with 100 to 500μg of Tromantadine inhibits herpes simplex virusinduced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500μg to 1mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection. Virion synthesis and viral polypeptide synthesis are inhibited by addition of Tromantadine at the time of infection or 4h postinfection. Tromantadine raises the bilayer to hexagonal phase transition temperature of synthetic phosphatidylethanolamines and is less disruptive to phospholipid packing. Tromantadine acts similar to cyclosporin A, previously demonstrated to inhibit viral-induced cell-cell fusion.

推荐实验方法(仅供参考)

细胞实验:

Cell Assay

Confluent monolayers of Vero (2.4x106 per plate) or HEp-2 (1.6x106 per plate) cells are treated with various amounts of Tromantadine 15min before and then throughout the infection and incubation. The dose of Tromantadine applied, rather than the concentration, is varied since, as for amantadine, the cells concentrate the compound from the medium. For most assays, cells are infected with 6x108 PFU of HSV-1 in 0.5mL for 1 h at 37°C, and the virus solution is then aspirated off the monolayer and replaced with 2mL of maintenance medium containing the same amount of the compound. The antiviral activity of the compounds is determined as a reduction in both virally induced cytopathic effect (CPE) and production of extracellular infectious virus 24, 48, and % h postinfection.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果