托美洛韦 - CAS:233254-24-5 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	托美洛韦
英文名称:	Tomeglovir
别名:	托美洛韦 N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide
CAS No:	233254-24-5	分子式:	C₂₃H₂₇N₃O₄S	分子量:	441.54
CAS No:	233254-24-5
分子式:	C₂₃H₂₇N₃O₄S
分子量:	441.54

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T10560 托美洛韦 ≥98% (psaitong)

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包装规格：

5mg 25mg 100mg in glass bottle

溶解性：

溶于DMSO（≥ 108 mg/mL)

产品描述：

基本信息

产品编号：T10560
产品名称：Tomeglovir
CAS:	233254-24-5	储存条件	粉末	-20℃	四年

分子式：	C23H27N3O4S		溶于液体	-80℃	六个月
分子量	441.54			-20℃	一个月
化学名：	N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide
Solubility (25°C)	体外	DMSO	≥108mg/mL (244.60mM)
		Ethanol
		Water
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.2648mL	11.3240mL	22.6480mL
5mM	0.4530mL	2.2648mL	4.5296mL
10mM	0.2265mL	1.1324mL	2.2648mL

生物活性

产品描述	一种抗 CMV 剂，能够抑制病毒 DNA 多联体的进程，对 HCMV 和 MCMV 的 IC50 值分别为 0.34μM 和 0.039μM。
靶点/IC₅₀	IC50: 0.34μM (HCMV) 0.039μM (MCMV)
体外研究	Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC50s of 0.34μM and 0.039μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC50s of 85μM and 62.5μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC50s of 1.03 ± 0.57μM and < 1μM.
体内研究	Tomeglovir (BAY 38-4766; 3, 10, 30, 100mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD50 is >2000 mg/kg in mice and rats

推荐实验方法(仅供参考)

细胞实验:

Cell Assay

In order to evaluate drug toxicity, 96-well microtitre plates are prepared with 100μL of EMEM/10 per well. After addition of 2μL of 50mM Tomeglovir stock solutions in duplicate into 198μL in row 2, serial two-fold dilutions are made with 100μL up to row 12 and 100μL of a HELF, NHDF or 3T3 cell suspension (5 × 103 cells/mL) are added per well. Row 1 serves as an untreated cell control. After incubation for 6 days at 37°C and 5% CO2, the cells are washed once with phosphate-buffered saline (PBS), and 200μL of a 10μg/mL fluorescent dye solution in PBS, pH 7.2 (fluorescein diacetate) are dispensed per well.After 45 min, the fluorescence signal is measured with a Fluorskan Ascent fluorimeter (excitation filter 485 ± 11nm, emission filter 530 ± 15nm). The relative fluorescence units (RFUs) of treated cells are expressed as percentages of untreated cell controls and CC50 values are determined graphically.

动物实验:

Animal Administration

Mice

NOD/LtSz-scid/j mice, 20-30 g body weight, are anesthesized with 0.015-0.017mL/g body weight Avertin 2.5% (Avertin 100% consists of 10 g tribromoethyl alcohol in 10mL tertiary amyl alcohol). After shaving and cleaning the belly aseptically, the abdomens are opened and the fibers inserted intra-abdominally. The abdomens are closed with two suture layers. Only asymptomatic animals are included in the study. Starting 1 day after transplantation, the mice are treated with the Tomeglovir at indicated dosages twice daily for four consecutive days per os. In preliminary experiments, viral peak titers are observed on day 5 under these conditions.

保存条件：

-20℃

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HazardClass：

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安全说明：

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