| 中文名称: | Tiplaxtinin | ||||
|---|---|---|---|---|---|
| 英文名称: | Tiplaxtinin | ||||
| 别名: | Tiplaxtinin PAI039;2-(1-benzyl-5-(4-(trifluoromethoxy)phenyl)-1H-indol-3-yl)-2-oxoacetic acid | ||||
| CAS No: | 393105-53-8 | 分子式: | C24H16F3NO4 | 分子量: | 439.38 |
| CAS No: | 393105-53-8 | ||||
| 分子式: | C24H16F3NO4 | ||||
| 分子量: | 439.38 | ||||
一种口服有效的选择性的PAI-1(纤溶酶原激活物抑制剂-1)抑制剂，IC50:2.7μM。
Tiplaxtinin is a novel plasminogen activator inhibitor-1 (PAI-1) inhibitor. The pharmacokinetic profile of PAI-039 indicated an oral bioavailability of 43 +/- 15.3% and a plasma half-life of 6.2 +/- 1.3 h. PAI-039 is an orally active prothrombolytic drug that inhibits PAI-1 and accelerates fibrinolysis while maintaining normal coagulation in a model of coronary occlusion . PAI-039 exerts antithrombotic efficacy in rat models of arterial and venous vascular injury without effecting platelet aggregation. PAI-039 as a novel therapeutic may improve diabetic wound closure.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
