| 中文名称: | SJ000291942 | ||||
|---|---|---|---|---|---|
| 英文名称: | SJ000291942 | ||||
| 别名: | 2-(4-ethylphenoxy)-N-(4-fluoro-3-nitrophenyl)acetamide | ||||
| CAS No: | 425613-09-8 | 分子式: | C16H15FN2O4 | 分子量: | 318.3 |
| CAS No: | 425613-09-8 | ||||
| 分子式: | C16H15FN2O4 | ||||
| 分子量: | 318.3 | ||||
包装规格：
2mg 5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：
SJ000291942 是经典骨形态发生蛋白 (BMP) 信号传导途径的激活剂。BMP 是转化生长因子 β (TGFβ) 分泌信号分子家族的成员。
溶解性：
溶解性(25°C)体外DMSO: 64 mg/mL (201.06 mM);乙醇:12 mg/mL (37.7 mM);水:不溶性
储备液保存：
-80°C 2 years
-20°C 1 year
-20°C 1 year
靶点：
BMP
体外研究：
Embryos treated with SJ000291942 display the most severe ventralization and SJ000291942 is also the most potent. SJ000291942 also causes more mortality, and at lower doses than controls and the other two compounds. This demonstrates our compounds cause ventralization of embryos consistent with increased BMP signaling activity. SJ000291942 causes an increase in bmp2b and szl expression. Zebrafish assays suggest that SJ000291942 activates the canonical BMP signaling pathway. To extend these observations, immunoblotting of protein lysates from C33A-2D2 cells stimulated with SJ000291942 at different times is performed. SJ000291942 activates phosphorylation of SMAD1/5/8 in serum-free medium. Like in zebrafish embryos, SJ000291942 is most active. SJ000291942 induces p-SMAD1/5/8 maximally at 1hr of treatment. Immunoblotting analysis of lysates from C33A-2D2 treated with SJ000291942 reveals clear induction of the phosphorylated Extracellular Signal-regulated protein Kinase, ERK1/2 (P-ERK1/2) by SJ000291942. The highest dose (100 and 300ng) BMP4 treatments generate a gene expression signature most similar to osteoblast expression. Low dose (10ng) BMP4 treatment aligns closely with 25μM compound 3 treatment and with 25μM SJ000291942.
保存条件：
-20°C
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
UN码：
HazardClass：
危害声明：
安全说明：
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参考文献 & 客户发表文献
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
