| 中文名称: | 索利那辛琥珀酸盐 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | Solifenacin succinate | ||||
| 别名: | (S)-(R)- 奎宁环-3-基1-苯基-3,4-二氢异喹啉-2(1H)-羧酸酯琥珀酸盐;索非那新琥珀酸盐 YM905;(S)-(R)-Quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate succinate | ||||
| CAS No: | 242478-38-2 | 分子式: | C27H32N2O6 | 分子量: | 480.55 |
| CAS No: | 242478-38-2 | ||||
| 分子式: | C27H32N2O6 | ||||
| 分子量: | 480.55 | ||||
基本信息
|
产品编号： |
S70045 |
||||
|
产品名称： |
Solifenacin succinate |
||||
|
CAS: |
242478-38-2 |
储存条件 |
粉末 |
2-8℃ |
四年 |
|
|
|
||||
|
分子式： |
溶于液体 |
-80℃ |
6个月 |
||
|
分子量 |
480.55 |
-20℃ |
1个月 |
||
|
化学名： |
(S)-(R)-Quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate succinate |
||||
|
Solubility (25°C)： |
|||||
|
体外:
|
DMSO |
3mg/mL (6.24mM) |
|||
|
Ethanol |
5mg/mL (10.4mM) |
||||
|
Water |
96mg/mL (199.77mM) |
||||
|
体内(现配现用): |
|
||||
|
＜1mg/ml表示微溶或不溶。 |
|||||
|
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
|||||
|
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
|||||
制备储备液
|
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
|
1mM |
2.0809mL |
10.4047mL |
20.8095mL |
|
5mM |
0.4162mL |
2.0809mL |
4.1619mL |
|
10mM |
0.2081mL |
1.0405mL |
2.0809mL |
|
50mM |
0.0416mL |
0.2081mL |
0.4162mL |
生物活性
|
产品描述 |
一种毒蕈碱受体 (muscarinic receptor) 拮抗剂。 |
|
靶点 |
mAChR |
|
体外研究 |
Solifenacin Succinate (YM905) is a novel muscarinic receptor antagonist with pKis of 7.6±0.056,6.9±0.034 and 8.0±0.021 for M1,M2 and M3 receptors,respectively.In murine submandibular gland cells, the antagonistic effects of 100 nM Solifenacin Succinate and oxybutynin on Ca2+ mobilization evoked by varying doses of carbachol (CCh) are examined.Solifenacin Succinate does not shift the CCh dose-activation curve in a parallel manner whereas oxybutynin shows insurmountable antagonism. The pKb values are obtained as 7.4±0.17 for Solifenacin Succinate and 8.8±0.21 for oxybutynin. |
|
体内研究 |
Solifenacin Succinate (YM905) reduces bladder responses by 40% at a dose of 210nmol/kg (0.1mg/kg) and abolishes them at 2100nmol/kg (1mg/kg).In contrast,its inhibitory effects on salivary and cardiac responses are only slight at 630nmol/kg (0.3mg/kg),and reach 66% and 49%,respectively, at 2100nmol/kg (1mg/kg).At doses of 63 and 210nmol/kg (0.03 and 0.1mg/kg),Solifenacin Succinate slightly increases saliva secretion.Solifenacin Succinate (0.01 to 0.3mg/kg i.v.) dosedependently increases bladder capacity and voided volume at doses of 0.03mg/kg i.v.or more,but does not affect residual volume or micturition pressure at any dose tested. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
