| 中文名称: | SNT-207707 | ||||
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| 英文名称: | SNT-207707 | ||||
| 别名: | 2-(4-Cyanophenyl)-N,N-bis(3-methylbutyl)-3-(3-pyrrolidin-1-ylpropyl)imidazo[1,2-a]pyridine-6-carboxamide;hydrochloride | ||||
| CAS No: | 1064662-40-3 | 分子式: | C32H44ClN5O | 分子量: | 550.18 |
| CAS No: | 1064662-40-3 | ||||
| 分子式: | C32H44ClN5O | ||||
| 分子量: | 550.18 | ||||
基本信息
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产品编号： |
S11182 |
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产品名称： |
SNT-207707 |
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CAS: |
1064662-40-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
358.18 |
-20℃ |
1个月 |
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化学名： |
2-(4-Cyanophenyl)-N,N-bis(3-methylbutyl)-3-(3-pyrrolidin-1-ylpropyl)imidazo[1,2-a]pyridine-6-carboxamide |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.8176mL |
9.0879mL |
18.1759mL |
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5mM |
0.3635mL |
1.8176mL |
3.6352mL |
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10mM |
0.1818mL |
0.9088mL |
1.8176mL |
生物活性
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产品描述 |
一种有效，选择性，有口服活性的黑素皮质素受体 (melanocortin MC-4) 拮抗剂，IC50 值为8nM (结合) 和5nM (功能)。 |
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靶点 |
8nM (binding MC-4),5nM (function MC-4) |
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体外研究 |
SNT-207707 binds to the MC-4 receptor with an affinity of 8nM and shows a more than 200-fold selectivity vs.MC-3 and MC5. SNT207858 is a 22nM MC-4 antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5. |
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体内研究 |
Single subcutaneous injection of 20mg/kg of SNT-207707 distinctly increases food intake of the mice. Once daily oral administration of both compounds SNT207858 and SNT-207707 starting the day after tumor implantation significantly reduces the tumor induced weight loss. |
推荐实验方法(仅供参考)
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动物实验: |
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Mice Twelve weeks old male CD-1 mice are dosed by gavage with either SNT-207707 or SNT207858 at 60mg/kg (n=9 per compound).At 1,3,and 6 hrs post-dose,3 mice from each compound group are euthanized with CO2.Blood is collected by cardiac puncture,plasma is isolated immediately and then kept on dry ice until analysis. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
