| 中文名称: | SR3335 | ||||
|---|---|---|---|---|---|
| 英文名称: | SR3335 | ||||
| 别名: | N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]-2-噻吩磺酰胺 ML 176 | ||||
| CAS No: | 293753-05-6 | 分子式: | C13H9F6NO3S2 | 分子量: | 405.34 |
| CAS No: | 293753-05-6 | ||||
| 分子式: | C13H9F6NO3S2 | ||||
| 分子量: | 405.34 | ||||
一种选择性的 RORα 反向激动剂，可直接结合 RORα，Ki为 220 nM。
SR3335, also known as ML 176, is a RORα selective inverse agonist. SR3335 directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Furthermore, SR3335 suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. SR3335 can be utilized as a chemical tool to probe the function of this receptor both in vitro and in vivo. SR3335 may hold utility for suppression of elevated hepatic glucose production in type 2 diabetics.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
