| 中文名称: | SB290157 trifluoroacetate | ||||
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| 英文名称: | SB290157 trifluoroacetate | ||||
| 别名: | N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate salt | ||||
| CAS No: | 1140525-25-2 | 分子式: | C22H28N4O4.Cf3Co2H | 分子量: | 526.51 |
| CAS No: | 1140525-25-2 | ||||
| 分子式: | C22H28N4O4.Cf3Co2H | ||||
| 分子量: | 526.51 | ||||
基本信息
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产品编号： |
S10891 |
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产品名称： |
SB290157 trifluoroacetate |
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CAS: |
1140525-25-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃(密封储存) |
6个月 |
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分子量： |
526.51 |
-20℃(密封储存) |
1个月 |
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化学名： |
N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate salt |
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Solubility (25°C)： |
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体外:
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DMSO |
100mg/mL (189.92mM) |
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Ethanol |
100mg/mL (189.92mM) |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.8993mL |
9.4965mL |
18.9930mL |
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5mM |
0.3799mL |
1.8993mL |
3.7986mL |
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10mM |
0.1899mL |
0.9496mL |
1.8993mL |
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50mM |
0.0380mL |
0.1899mL |
0.3799mL |
生物活性
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产品描述 |
一种有效，选择性的C3a受体的拮抗剂。 |
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靶点 |
RBL-C3aR |
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200nM |
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体外研究 |
SB 290157,functions as a competitive antagonist of 125I-C3a radioligand binding to rat basophilic leukemia-2H3 cells expressing the human C3aR (RBL-C3aR),with an IC50 of 200nM.SB 290157 blocks C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca2+ mobilization in RBL-C3aR cells and human neutrophils with IC50s f 27.7 and 28nM,respectively.SB 290157 is selective for the C3aR in that it does not antagonize the C5aR or six other chemotactic G protein-coupled receptors.SB 290157 also inhibits C3a-induced Ca2+ mobilization of RBL-2H3 cells expressing the mouse and guinea pig C3aRs.It potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery. |
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体内研究 |
SB 290157,inhibits neutrophil recruitment in a guinea pig LPS-induced airway neutrophilia model and decreases paw edema in a rat adjuvant-induced arthritis model.The antagonist is able to reduce joint swelling only at 3h,and about 50% inhibition of joint swelling is observed with the concentration of 30mg/kg.The C3 level is significantly decreased at 3h compared with naive mice showing complement consumption.Furthermore,the C3 activation is observed and increased corresponding to the graded concentration of anti-OVA pAb. |
推荐实验方法(仅供参考)
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动物实验: |
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Rats:SB 290157 is administered b.i.d.at 30,10,and 3mg/kg i.p.in a final volume of 0.5mL starting on the day of adjuvant injection.Cages are modified to allow the compromised animals free access to food and water.Control animals are given vehicle alone.Change in paw volume is presented as mean and SEM of 10-12 animals/group,and the percentage inhibition of hind paw edema is calculated.
Mice: Administration of SB 290157,a C3aR antagonist,(10 or 30mg/kg) is injected i.p.two times,at 0 (right after OVA injection) and 2h while 5% ethanol in PBS is used as a vehicle control.Joint swelling is measured using a dial thickness gauge before injection,at 0.5h,and then every hour until 5h after OVA injection. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
