中文名称: | Rabusertib | ||||
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英文名称: | Rabusertib | ||||
别名: | LY2603618 抑制剂;N-[5-溴-4-甲基-2-[(2S)-2-吗啉甲氧基]苯基]-N'-(5-甲基-2-吡嗪基)脲;N-[5-溴-4-甲基-2-[(2S)-2-吗啉甲氧基]苯基]-N-(5-甲基-2-吡嗪基)脲;LY2603618 国华试剂;LY2603618 国华试剂 LY2603618;(S)-1-(5-bromo-4-methyl-2-(morpholin-2-ylmethoxy)phenyl)-3-(5-methylpyrazin-2-yl)urea | ||||
CAS No: | 911222-45-2 | 分子式: | C18H22BrN5O3 | 分子量: | 436.3 |
CAS No: | 911222-45-2 | ||||
分子式: | C18H22BrN5O3 | ||||
分子量: | 436.3 |
一种有效的选择性的Chk1抑制剂,IC50:7nM。
Rabusertib is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )