| 中文名称: | Rostafuroxin | ||||
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| 英文名称: | Rostafuroxin | ||||
| 别名: | Rostafuroxin (PST 2238) 抑制剂;乙肼草酸盐 PST2238;3S,5R,8R,9S,10S,13S,14S,17S)-17-(furan-3-yl)-10,13-dimethylhexadecahydro-14H-cyclopenta[a]phenanthrene-3,14,17-triol | ||||
| CAS No: | 156722-18-8 | 分子式: | C23H34O4 | 分子量: | 374.52 |
| CAS No: | 156722-18-8 | ||||
| 分子式: | C23H34O4 | ||||
| 分子量: | 374.52 | ||||
基本信息
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产品编号： |
R10157 |
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产品名称： |
Rostafuroxin |
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CAS: |
156722-18-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
374.52 |
-20℃ |
1个月 |
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化学名： |
3S,5R,8R,9S,10S,13S,14S,17S)-17-(furan-3-yl)-10,13-dimethylhexadecahydro-14H-cyclopenta[a]phenanthrene-3,14,17-triol |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.6702mL |
13.3508mL |
26.7016mL |
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5mM |
0.5340mL |
2.6702mL |
5.3403mL |
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10mM |
0.2670mL |
1.3351mL |
2.6702mL |
生物活性
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产品描述 |
一种Na+K ATPase拮抗剂。 |
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靶点 |
Na+/K+ATPase;RSV |
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体外研究 |
Rostafuroxin (PST 2238) competitively inhibits Ouabain (HY-B0542) binding and signaling.Rostafuroxin antagonizes the molecularand functional effects of Ouabain by reversing the ouabain-induced,Src-dependent Na+,K+-ATPase phosphorylation and activation.Rostafuroxin (0.125-128μM;for 24h post treatment) has less than 20% reduction in cell viability in A549 cells and HSAEC.Rostafuroxin inhibits the expression of RSV-GFP in HSAEC (IC50=1.8μM) and A549 cells (IC50=14.8μM).Rostafuroxin displaced [3H]Ouabain from the dog kidney Na+,K+-ATPase receptor (IC50=1.5nM),is devoid of cardiac inotropic activity in isolated guinea pig atria,and shows no affinity up to 10-4 M with general (R1,R2,a1,a2,A1,A2,M1,M2,H1,H2,5-HT1,5-HT2,Ca2+ channels,TXA2/PGH2,PAF,GABAA,GABAB,DA-NE-5-HT uptake,glutammate,glycine,benzodiazepine) and hormonal (estrogenic,progestinic,androgenic,mineralcorticoid) receptors. |
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体内研究 |
Rostafuroxin (PST 2238;1mg/kg/day;gavage;for 3 weeks) decreases SBP and improves acetylcholine-induced relaxation. |
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Animal Model: |
Male 7-week-old Wistar rats |
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Dosage: |
1mg/kg |
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Administration: |
Gavage;daily;for 3 weeks |
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Result: |
Decreased SBP,improved acetylcholine-induced relaxation via enhanced nitric oxide synthesis and bioavailability,decreased superoxide anion generation from NAD(P)H oxidase and cyclooxygenase-2 and reduced cytoplasmic tyrosine kinase Src phosphorylation. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
