| 中文名称: | PSB-12062 | ||||
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| 英文名称: | PSB-12062 | ||||
| 别名: | PSB-12062 N-(p-Methylphenylsulfonyl)phenoxazine | ||||
| CAS No: | 55476-47-6 | 分子式: | C19H15NO3S | 分子量: | 337.39 |
| CAS No: | 55476-47-6 | ||||
| 分子式: | C19H15NO3S | ||||
| 分子量: | 337.39 | ||||
基本信息
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产品编号： |
P11284 |
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产品名称： |
PSB-12062 |
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CAS: |
55476-47-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
337.39 |
-20℃ |
1个月 |
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化学名： |
N-(p-Methylphenylsulfonyl)phenoxazineN-(p-Methylphenylsulfonyl)phenoxazine |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.9639mL |
14.8196mL |
29.6393mL |
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5mM |
0.5928mL |
2.9639mL |
5.9279mL |
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10mM |
0.2964mL |
1.4820mL |
2.9639mL |
生物活性
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产品描述 |
一种有效，选择性的P2X4拮抗剂，对人类P2X4的IC50值为1.38μM。 |
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靶点 |
IC50:1.38μM (human P2X4),92.8nM (rat P2X4),1.76μM (mouse P2X4) |
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体外研究 |
PSB-12062 shows similar potency in human,rat,and mouse species.PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1,P2X2,P2X3,and P2X7.However,PSB-12062 is unable to completely block ATPinduced P2X4-mediated calcium influx even when used at high concentrations (>30μM). |
推荐实验方法(仅供参考)
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激酶实验： |
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The competition binding studies are performed in assay buffer (50mM Tris-HCl,pH 7.4) containing 1mM EDTA and 0.2nM [35S]ATPγS.The incubations are started by the addition of membranes (10-15μg) and are performed in a 250μL final assay volume.The reactions are terminated by vacuum filtration over GF/ B glass-fiber filters using a Brandell 48-well harvester.The filters are rinsed three times with ice-cold Tris-HCl buffer (50mM,pH 7.4).The filters are punched out and transferred to 4mL scintillation vials.Then 2.5mL of Ultima Gold scintillation cocktail is added,and samples are counted after 6h for 1 min each,using a liquid scintillation counter (LSC).Nonspecific binding of [35S]ATPγS is determined using 100μM ATP. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
