| 中文名称: | 丙谷胺钠 | ||||
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| 英文名称: | Proglumide sodium | ||||
| 别名: | 蒙胃顿钠 Pentanoic acid,4-(benzoylamino)-5-(dipropylamino)-5-oxo-, sodium salt (1:1);PROGLUMIDE SODIUM SALT | ||||
| CAS No: | 99247-33-3 | 分子式: | C18H25N2NaO4 | 分子量: | 356.39 |
| CAS No: | 99247-33-3 | ||||
| 分子式: | C18H25N2NaO4 | ||||
| 分子量: | 356.39 | ||||
基本信息
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产品编号： |
P11005 |
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产品名称： |
Proglumide sodium |
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CAS: |
99247-33-3 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃(氮气储存) |
6个月 |
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分子量： |
356.39 |
-20℃(氮气储存) |
1个月 |
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化学名： |
Pentanoic acid,4-(benzoylamino)-5-(dipropylamino)-5-oxo-, sodium salt (1:1);PROGLUMIDE SODIUM SALT |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.8059mL |
14.0296mL |
28.0591mL |
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5mM |
0.5612mL |
2.8059mL |
5.6118mL |
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10mM |
0.2806mL |
1.4030mL |
2.8059mL |
生物活性
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产品描述 |
一种非肽和口服活性胆囊收缩素 (CCK)-A/B 受体拮抗剂。Proglumide sodium 选择性阻断 CCK 在中枢神经系统中的作用。Proglumide sodium 具有抑制胃分泌和保护胃十二指肠粘膜的能力，还具有抗癫痫和抗氧化活性。 |
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靶点 |
Cholecystokinin (CCK)-A/B receptors |
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体外研究 |
In an in vitro study,Proglumide at concentrations between 0.3-10mM inhibits CCK-stimulated amylase release dosedependently, while Proglumide does not influence the basal amylase release at concentrations between 0-mM.Doseresponse curves to CCK for amylase release shifted to the right with increase in Proglumide concentration.This inhibition by Proglumide is reversible.In addition,the effect of Proglumide is selective for CCK and its related peptide.The incubation of HT29 cells with Proglumide significantly reduces the [3H]-thymidine incorporation to HT29 cells in a dosedependent manner, with an IC50 of 6.5mM.Proglumide reduces in a dose-dependent manner the percentage of necrosis with a parallel increase of apoptosis up to 70%. |
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体内研究 |
Proglumide (250-750mg/kg;intraperitoneal injection;adult male Sprague Dawley rats) treatment is significantly effective in ameliorating the seizure activities,cognitive dysfunctions,and cerebral oxidative stress. |
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Animal Model: |
Adult male Sprague Dawley rats (200-250g;2 months old) are induced status epilepticus (SE) |
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Dosage: |
250mg/kg,500mg/kg,and 750mg/kg |
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Administration: |
Intraperitoneal injection |
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Result: |
Dose-dependently and significantly increased the latencies to seizure and SE.Significantly and dose-dependently attenuated Li-PC (SE) induced increase in thiobarbituric acid (TBARS) and catalase (CAT),attenuated Li-Pc induced decrease in SOD,and attenuated depletion of GSH and glutathione-S transferase (GST) in the hippocampus and striatum. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
