| 中文名称: | Pevonedistat 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | Pevonedistat | ||||
| 别名: | MLN-4924；TAK 924；((1S,2S,4R)-4-(4-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate | ||||
| CAS No: | 905579-51-3 | 分子式: | C21H25N5O4S | 分子量: | 443.52 |
| CAS No: | 905579-51-3 | ||||
| 分子式: | C21H25N5O4S | ||||
| 分子量: | 443.52 | ||||
一种NAE（NEDD8激活酶)抑制剂，IC50:4nM，具有潜在的抗肿瘤活性。
Pevonedistat is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with potential antineoplastic activity. NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival. NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP)。
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
