| 中文名称: | OTS-964 HCL | ||||
|---|---|---|---|---|---|
| 英文名称: | OTS-964 HCL | ||||
| 别名: | (R)-9-[4-[1-(二甲基氨基)丙-2-基]苯基]-8-羟基-6-甲基噻吩并[2,3-c]喹啉-4(5H)-酮盐酸盐 OTS964 hydrochloride (R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one hydrochloride | ||||
| CAS No: | 1338545-07-5 | 分子式: | C23H24N2O2S.HCl | 分子量: | 428.97 |
| CAS No: | 1338545-07-5 | ||||
| 分子式: | C23H24N2O2S.HCl | ||||
| 分子量: | 428.97 | ||||
一种高效、选择性的具有潜在抗癌活性的TOPK抑制剂,IC50:28nM。
OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), this inhibitor causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. Although administration of the free compound induced hematopoietic adverse reactions (leukocytopenia associated with thrombocytosis), the drug delivered in a liposomal formulation effectively caused complete regression of transplanted tumors without showing any adverse reactions in mice.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
