| 中文名称: | NCT-501 | ||||
|---|---|---|---|---|---|
| 英文名称: | NCT-501 | ||||
| 别名: | NCT-501 8-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)-7-isopentyl-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione | ||||
| CAS No: | 1802088-50-1 | 分子式: | C21H32N6O3 | 分子量: | 416.52 |
| CAS No: | 1802088-50-1 | ||||
| 分子式: | C21H32N6O3 | ||||
| 分子量: | 416.52 | ||||
一种茶碱类的有效醛脱氢酶1A1(ALDH1A1)选择性抑制剂,抑制hALDH1A1时IC50值为40nM,选择性超过其它ALDH同工酶和其它脱氢酶(作用于hALDH1B1,hALDH3A1,和hALDH2时,IC50值>57UM)。
NCT-501 is a potent ALDH1A1 inhibitor. Aldehyde dehydrogenases (ALDHs) metabolize reactive aldehydes and possess important physiological and toxicological functions in areas such as CNS, metabolic disorders, and cancers. Increased ALDH (e.g., ALDH1A1) gene expression and catalytic activity are vital biomarkers in a number of malignancies and cancer stem cells, highlighting the need for the identification and development of small molecule ALDH inhibitors.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
