| 中文名称: | Nodinitib-1 | ||||
|---|---|---|---|---|---|
| 英文名称: | Noditinib-1 | ||||
| 别名: | 1-[(4-Methylphenyl)sulfonyl]-1H-benzimidazol-2-amine ML130 | ||||
| CAS No: | 799264-47-4 | 分子式: | C14H13N3O2S | 分子量: | 287.34 |
| CAS No: | 799264-47-4 | ||||
| 分子式: | C14H13N3O2S | ||||
| 分子量: | 287.34 | ||||
| MDL: | MFCD04322367 | ||||
一种有效的选择性的核苷酸结合寡聚域样受体1(NOD1)抑制剂.IC50:0.56 μM.
Nodinitib-1（ML130） selectively inhibits IL-8 production induced by NOD1 ligand. Nodinitib-1 also inhibits γ-tri-DAP-induced expression of the prototypical NF-κB target gene IκBα at the mRNA level. Nodinitib-1 inhibits γ-tri-DAP-dependent activation of NF-κB (IκBα phosphorylation and degradation) and MAPK (p38 phosphorylation) signalings, without affecting Akt survival pathway. Nodinitib-1 selectively inhibits responses of primary dendritic cells to NOD1 ligand. Nodinitib-1 reduces cell surface expression of co-stimulatory molecules CD83, CD86 and HLA-DR and also inhibits expression of IL-1β, IL-6 and TNFα elicited by γ-tri-DAP (but not by LPS), without causing cytoxicity. Nodinitib-1 is identified as NOD1-selective molecules from an HTS campaign involving ~290,000 compounds. Nodinitib-1 inhibits γ-tri-DAP-stimulated luciferase production in HEK 293T cells, which has endogenous NOD1 levels at submicromolar concentration as determined in a NF-κB-linked reporter assay.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
