中文名称: | 米托蒽醌二盐酸盐 | ||||
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英文名称: | Mitoxantrone dihydrochloride | ||||
别名: | 盐酸米托蒽醌 mitozantrone dihydrochloride | ||||
CAS No: | 70476-82-3 | 分子式: | C22H28N4O6.2HCl | 分子量: | 517.4 |
CAS No: | 70476-82-3 | ||||
分子式: | C22H28N4O6.2HCl | ||||
分子量: | 517.4 | ||||
EINEC: | 274-619-1 | ||||
EINEC: | 274-619-1 |
一种拓扑异构酶II (topoisomerase II)的抑制剂;也可抑制蛋白激酶C (PKC), IC50值为8.5 μM。
Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation. It also inhibits HIV-1 integrase (IC50 = 3.8 μM). Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1.4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )