MP7 - CAS:1001409-50-2 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	MP7
英文名称:	MP7
别名:	PDK1 抑制剂 1-[(3,4-difluorophenyl)methyl]-2-oxo-N-[(1R)-2-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)oxy]-1-phenylethyl]pyridine-3-carboxamide；PDK1 inhibitor
CAS No:	1001409-50-2	分子式:	C₂₈H₂₂F₂N₄O₄	分子量:	516.5
CAS No:	1001409-50-2
分子式:	C₂₈H₂₂F₂N₄O₄
分子量:	516.5

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

M11674 MP7 ≥98% (psaitong)

相关产品

包装规格：

5mg 10mg 50mg 100mg in glass bottle

溶解性：

溶于DMSO(≥100mg/mL）

产品描述：

基本信息

产品编号：	M11674
产品名称：	MP7
CAS:	1001409-50-2	储存条件	粉末	-20℃	四年

分子式：	C28H22F2N4O4		溶于液体	-80℃	6个月
分子量：	516.50			-20℃	1个月
化学名：	1-[(3,4-difluorophenyl)methyl]-2-oxo-N-[(1R)-2-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)oxy]-1-phenylethyl]pyridine-3-carboxamide；PDK1 inhibitor
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	1.9361mL	9.6805mL	19.3611mL
5mM	0.3872mL	1.9361mL	3.8722mL
10mM	0.1936mL	0.9681mL	1.9361mL

生物活性

产品描述	一种磷酸肌醇依赖性激酶-1 (PDK1)抑制剂。
靶点	PDK1
体外研究	Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e.,1.5μM Alisertib and 2.5μM MP7),a significant enhancement in the number of dead cells is evidenced.Following 72h treatment,MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation.MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines,with IC50 values in the micromolar range.

推荐实验方法(仅供参考)

细胞实验:

The human GBM cells (i.e.,U87MG,U343MG,or ANGM-CSS) or the respective GSCs are seeded and incubated for the indicated times with the indicated concentrations of SA16 (1nM to 100μM),MP7 (2.5nM,25nM,250nM and 2.5μM),or Alisertib.When indicated,cells are treated with MP7 and Alisertib in combination.To verify GSC chemoresistance,U87MG or GSCs are incubated with 50μM TMZ for 72h.For the long-term treatment of cells,NSC or complete medium containing drugs is replaced every 3 days.Cell proliferation is determined using the MTS assay:the dehydrogenase activity in active mitochondria reduces MTS to the soluble formazan product,whose absorbance at 490nm is measured with an automated plate reader.The mean background from each test condition is subtracted,and the data are expressed as the percentage of untreated cells (control).IC50 values are derived from the sigmoid dose-response curve.The percentage of inhibition is calculated as 100% minus the percentage of cell proliferation.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果