| 中文名称: | ML329 | ||||
|---|---|---|---|---|---|
| 英文名称: | ML329 | ||||
| 别名: | 4-((1,4-二氧代-1,4-二氢萘-2-基)氨基)苯磺酰胺 4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide | ||||
| CAS No: | 19992-50-8 | 分子式: | C16H12N2O4S | 分子量: | 328.342 |
| CAS No: | 19992-50-8 | ||||
| 分子式: | C16H12N2O4S | ||||
| 分子量: | 328.342 | ||||
一种小眼畸形相关转录因子 (MITF) 抑制剂，ML329 抑制 TRPM-1 启动子活性，IC50 值为 1.2 μM。
ML-329 is an inhibitor of the microphthalmia-associated transcription factor (MITF) pathway with an IC50 value of 1.2 μM for promoter activity of the MITF target gene TRPM-1. ML329 showed specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduced the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
