| 中文名称: | MF-438 | ||||
|---|---|---|---|---|---|
| 英文名称: | MF-438 | ||||
| 别名: | 2-甲基-5-(6-(4-(2-(三氟甲基)苯氧基)哌啶-1-基)哒嗪-3-基)-1,3,4-噻二唑 2-Methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole | ||||
| CAS No: | 921605-87-0 | 分子式: | C19H18F3N5Os | 分子量: | 421.44 |
| CAS No: | 921605-87-0 | ||||
| 分子式: | C19H18F3N5Os | ||||
| 分子量: | 421.44 | ||||
一种有效且口服生物可利用的 stearoyl-CoA desaturase 1 (SCD1) 的抑制剂，对 rSCD1 的 EC50 值为 2.3 nM。
MF-438 is a potent and orally bioavailable SCD inhibitor. MF-438 exhibits good pharmacokinetics and metabolic stability, thereby serving as a valuable tool for further understanding the role of SCD inhibition in biological and pharmacological models of diseases related to metabolic disorders. Co-treatment with cisplatin and MF-438 reverts upregulation of CSCs markers, strongly synergizes in the inhibition of 3D spheroids formation and induces CSCs apoptosis.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
