| 中文名称: | M77976 | ||||
|---|---|---|---|---|---|
| 英文名称: | M77976 | ||||
| 别名: | M77976 4-[4-(4-Methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol | ||||
| CAS No: | 394237-61-7 | 分子式: | C17H16N2O3 | 分子量: | 296.32 |
| CAS No: | 394237-61-7 | ||||
| 分子式: | C17H16N2O3 | ||||
| 分子量: | 296.32 | ||||
一种特异性的，ATP竞争性的丙酮酸脱氢酶激酶PDK4抑制剂，其作用的IC50值为648μM。M77976有用于肥胖症和糖尿病研究的潜力。
M77976 is a PDK4 inhibitor (human pyruvate dehydrogenase kinase 4). M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid. M77976 binding also leads to a large domain rearrangement that further expands the active-site cleft of PDK4 compared with the ADP- and AMPPNP-bound forms. Biochemical analyses revealed that M77976 inhibits PDK4 with increased potency compared with the previously characterized PDK inhibitor radicicol.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
