Merimepodib - CAS:198821-22-6 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Merimepodib
英文名称:	Merimepodib
别名:	美泊地布 VX-497; MMPD
CAS No:	198821-22-6	分子式:	C₂₃H₂₄N₄O₆	分子量:	452.46
CAS No:	198821-22-6
分子式:	C₂₃H₂₄N₄O₆
分子量:	452.46

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M10626 Merimepodib ≥98% (psaitong)

相关产品

包装规格：

2mg 5mg 10mg 25mg 50mg in glass bottle

溶解性：

溶于DMSO（≥ 31 mg/mL)

产品描述：

基本信息

产品编号：M10626
产品名称：Merimepodib
CAS:	198821-22-6	储存条件	粉末	-20℃	四年

分子式：	C23H24N4O6		溶于液体	-80℃	两年
分子量	452.46			-20℃	一个月
化学名：	[(3S)-oxolan-3-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate
Solubility (25°C)	体外	DMSO	90mg/mL (198.91mM)
		Ethanol	Insoluble
		Water	Insoluble
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.2101mL	11.0507mL	22.1014mL
5mM	0.4420mL	2.2101mL	4.4203mL
10mM	0.2210mL	1.1051mL	2.2101mL
50mM	0.0442mL	0.2210mL	0.4420mL

生物活性

产品描述	非竞争型，有口服活性的肌苷一磷酸脱氢酶抑制剂，具有广谱抗病毒活性。
靶点/IC₅₀	IMPDH ()
体外研究	VX-497 has antiproliferative effect on lymphoid and keratinocyte cells. The antiproliferative effect of VX-497 in cells is reversed within 48h of its removal. VX-497 has intermediate antiviral activity against a second group of viruses, which includes HSV-1, parainfluenza-3 virus, BVDV, VEEV, and dengue virus, with IC50s ranging from 6 to 19μM. VX-497 is 100-fold more potent, with an IC50 of 380nM and a corresponding CC50 of 5.2μM, for a therapeutic index of 14. The antiviral activity of VX-497 in HepG2.2.2.15 cells is reversed threefold by the addition of guanosine.
体内研究	Oral administration of VX-497 inhibits the primary IgM antibody response in a dose-dependent manner, with an ED50 value of appr 30-35mg/kg in mice. Single daily dosing of VX-497 is observed to be as effective as twice-daily dosing in this model of immune activation. GVHD developed in the vehicle-treated allografted F1 mice and treatment with VX-497 improved all manifestations of the disease significantly. The 2.9-fold increase in spleen weight in allografted animals is reduced to a 1.6- fold increase in the VX-497-treated mice. Serum IFN-gamma levels are increased 54-fold in the vehicle group while there is a 7.4-fold increase in VX-497-treated animals.

推荐实验方法(仅供参考)

细胞实验:

Cell Assay

The murine fibroblast L929 cell line is cultured in Eagle minimal essential medium supplemented with 10% fetal bovine serum, nonessential amino acids, 50 U of penicillin per mL, 50μg of streptomycin per mL, and 2mM l-glutamine. EMCV is infected at 500 PFU/107 L929 cells. Cells are left untreated or are treated with different concentrations of murine IFN-α alone, VX-497 alone, or combinations thereof.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果