| 中文名称: | ML-265 | ||||
|---|---|---|---|---|---|
| 英文名称: | ML-265 | ||||
| 别名: | CID44246499;ML265;TEPP46;6-(3-aminobenzyl)-4-methyl-2-(methylsulfinyl)-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one | ||||
| CAS No: | 1221186-53-3 | 分子式: | C17H16N4O2S2 | 分子量: | 372.46 |
| CAS No: | 1221186-53-3 | ||||
| 分子式: | C17H16N4O2S2 | ||||
| 分子量: | 372.46 | ||||
一种有效的选择性的丙酮酸激酶M2(pyruvate kinase M2; PKM2)激活剂。
ML265 is a potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model. Cancer cells have altered metabolic processes compared to normal differentiated cells and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this aberrant metabolism. ML265 induces the more active tetrameric state of PKM2 and the X-ray co-crystal structure shows that the activator binds at the dimer-dimer interface between two subunits of PKM2. ML265 was tested in a H1299 mouse xenograft model and showed significant reduction in tumor size, weight, and occurrence with no apparent toxicity over the 7-week experiment.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
