| 中文名称: | MK-1775 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | MK-1775 | ||||
| 别名: | 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one;AZD1775;Adavosertib | ||||
| CAS No: | 955365-80-7 | 分子式: | C27H32N8O2 | 分子量: | 500.6 |
| CAS No: | 955365-80-7 | ||||
| 分子式: | C27H32N8O2 | ||||
| 分子量: | 500.6 | ||||
![1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, 2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-](http:///www.jm-bio.com/content/xtheme/beijingjinming/images/noimage.jpg)
一种WEE1抑制剂，IC50：5.2nM，具有潜在的抗肿瘤增敏活性。
MK-1775 is a WEE1 inhibitor, is also a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents。
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
