| 中文名称: | LQZ-7I | ||||
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| 英文名称: | LQZ-7I | ||||
| CAS No: | 195822-23-2 | 分子式: | C20H14F2N4 | 分子量: | 348.35 |
| CAS No: | 195822-23-2 | ||||
| 分子式: | C20H14F2N4 | ||||
| 分子量: | 348.35 | ||||
基本信息
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产品编号：L10347 |
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产品名称：LQZ-7I |
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CAS: |
195822-23-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
348.35 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
70mg/mL (200.94mM) |
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Ethanol |
70mg/mL (200.94mM) |
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Water |
Insoluble |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.8707mL |
14.3534mL |
28.7068mL |
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5mM |
0.5741mL |
2.8707mL |
5.7414mL |
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10mM |
0.2871mL |
1.4353mL |
2.8707mL |
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50mM |
0.0574mL |
0.2871mL |
0.5741mL |
生物活性
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产品描述 |
一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。 |
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靶点/IC50 |
survivin |
survivin |
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4.8µM(ic50) |
3.1µM(ic50) |
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体外研究 |
LQZ-7I has improved cytotoxicity with IC50s of 3.1µM against C4-2 cells and 4.8µM against PC-3 cells compared with the parent compound LQZ-7.LQZ-7I (10µM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin. Western Blot Analysis |
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Cell Line: |
PC-3 or C4-2 cells |
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Concentration: |
10µM |
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Incubation Time: |
0-6 hours |
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Result: |
Reduced the expression of survivin. |
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体内研究 |
LQZ-7I (100mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice. |
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Animal Model: |
6-week old male NSG mice |
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Dosage: |
100mg/kg; 200µL vehicle (90% corn oil/10% DMSO) |
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Administration: |
Oral gavage every other day for a total of ten treatments |
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Result: |
Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
