| 中文名称: | Sodium ilaprazole | ||||
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| 英文名称: | Sodium ilaprazole | ||||
| 别名: | Sodium ilaprazole IY-81149sodium | ||||
| CAS No: | 172152-50-0 | 分子式: | C19H17N4NaO2S | 分子量: | 388.42 |
| CAS No: | 172152-50-0 | ||||
| 分子式: | C19H17N4NaO2S | ||||
| 分子量: | 388.42 | ||||
基本信息
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产品编号： |
I10362 |
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产品名称： |
Sodium ilaprazole |
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CAS: |
172152-50-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃(避光) |
6个月 |
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分子量： |
388.42 |
-20℃(避光) |
1个月 |
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化学名： |
sodium;2-[(4-methoxy-3-methylpyridin-2-yl)methylsulfinyl]-5-pyrrol-1-ylbenzimidazol-3-ide |
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Solubility (25°C)： |
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体外:
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DMSO |
78mg/mL (200.81mM) |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.5745mL |
12.8727mL |
25.7453mL |
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5mM |
0.5149mL |
2.5745mL |
5.1491mL |
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10mM |
0.2575mL |
1.2873mL |
2.5745mL |
生物活性
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产品描述 |
一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为6μM。Ilaprazolesodium用于胃溃疡的研究。Ilaprazolesodium也是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。 |
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靶点 |
Proton Pump |
TOPK |
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体外研究 |
On cumulation of 14C-aminopyrine in histamine stimulated parietal cells,the IC50 of Ilaprazole (IY-81149) sodium is 9nM. |
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体内研究 |
Ilaprazole sodium (3-30mg/kg;i.d.) dose-dependently inhibits gastric acid secretion.In anesthetized rats,Ilaprazole sodium dose-dependently increases gastric pH which is lowered by histamine infusion. In the case of i.v.injection,the ED50 of Ilaprazole sodium and Omeprazole is 1.2 and 1.4mg/kg and in the case of i.d.administration,the ED50 of Ilaprazole sodium and omeprazole is 3.9 and 4.1mg/kg,respectively.Ilaprazole sodium also significantly inhibits pentagastrin-stimulated gastric secretion.Its ED50 is 2.1mg/kg and that of Omeprazole was 3.5mg/kg with i.d.administration. In the case of i.v.injection,Ilaprazole sodium is equipotent to Omeprazole. Ilaprazole sodium also inhibits gastric acid secretion strongly in fistular rats.The ED50 of Ilaprazole sodium administered intraduodenally is 0.43mg/kg and that of omeprazole Is 0.68mg/kg. |
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Animal Model: |
Male SD rat (after pylorus ligation) |
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Dosage: |
3,10,30mg/kg |
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Administration: |
Intraduodenally |
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Result: |
The acid output and volume significantly inhibited by about 60% and 46% at 3mg/kg were s,respectively.At 30mg/kg,it showed 93% and 73% inhibition on acid output and volume,respectively. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
