| 中文名称: | Ilaprazole 促销 | ||||
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| 英文名称: | Ilaprazole | ||||
| 别名: | 艾普拉唑 IY-81149 | ||||
| CAS No: | 172152-36-2 | 分子式: | C19H18N4O2S | 分子量: | 366.44 |
| CAS No: | 172152-36-2 | ||||
| 分子式: | C19H18N4O2S | ||||
| 分子量: | 366.44 | ||||
基本信息
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产品编号： |
I10361 |
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产品名称： |
Ilaprazole |
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CAS: |
172152-36-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
366.44 |
-20℃ |
1个月 |
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化学名： |
2-[(4-METHOXY-3-METHYL-PYRIDIN-2-YL)METHYLSULFINYL]-5-PYRROL-1-YL-3H-BENZOIMIDAZOLE |
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Solubility (25°C)： |
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体外:
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DMSO |
73mg/mL (199.21mM) |
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Ethanol |
14mg/mL (38.2mM) |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.7290mL |
13.6448mL |
27.2896mL |
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5mM |
0.5458mL |
2.7290mL |
5.4579mL |
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10mM |
0.2729mL |
1.3645mL |
2.7290mL |
生物活性
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产品描述 |
一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为6μM。Ilaprazole用于胃溃疡的研究。Ilaprazole也是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。 |
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靶点 |
IC50:6.0μM (H+/K+-ATPase) |
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体外研究 |
On cumulation of 14C-aminopyrine in histamine stimulated parietal cells,the IC50 of Ilaprazole (IY-81149) sodium is 9nM. |
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体内研究 |
Ilaprazole (3-30mg/kg;i.d.) dose-dependently inhibits gastric acid secretion.In anesthetized rats,Ilaprazole dose-dependently increased gastric pH which was lowered by histamine infusion.In the case of i.v.injection,the ED50 of Ilaprazole and omeprazole is 1.2 and 1.4mg/kg and in the case of i.d.administration,the ED50 of Ilaprazole and omeprazole is 3.9 and 4.1mg/kg,respectively.Ilaprazole also significantly inhibits pentagastrin-stimulated gastric secretion.Its ED50 is 2.1mg/kg and that of Omeprazole is 3.5mg/kg with i.d.administration.In the case of i.v.injection,Ilaprazole is equipotent to Omeprazole.Ilaprazole also inhibits gastric acid secretion strongly in fistular rats.The ED50 of Ilaprazole administered intraduodenally is 0.43mg/kg and that of Omeprazole is 0.68mg/kg. |
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Animal Model: |
Male SD rat (after pylorus ligation) |
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Dosage: |
3,10,30mg/kg |
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Administration: |
Intraduodenally |
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Result: |
The acid output and volume significantly inhibited by about 60% and 46% at 3mg/kg were s,respectively.At 30mg/kg,it showed 93% and 73% inhibition on acid output and volume,respectively. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
