| 中文名称: | HMN-214 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | HMN-214 | ||||
| 别名: | N-(4-methoxyphenyl)sulfonyl-N-[2-[(E)-2-(1-oxidopyridin-1-ium-4-yl)ethenyl]phenyl]acetamide N-(4-methoxyphenyl)sulfonyl-N-[2-[(E)-2-(1-oxidopyridin-1-ium-4-yl)ethenyl]phenyl]acetamide | ||||
| CAS No: | 173529-46-9 | 分子式: | C22H20N2O5S | 分子量: | 424.47 |
| CAS No: | 173529-46-9 | ||||
| 分子式: | C22H20N2O5S | ||||
| 分子量: | 424.47 | ||||
| MDL: | MFCD12756255 | ||||
HMN-214是HMN-176的前体药物，是一种有效的、广泛的肿瘤特异性试剂。
HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk) with IC50 of 118 nM. HMN-214 shows potent and broad-spectrum anti-tumor activity against various cancer cells, including HeLa, PC-3, DU-145, MIAPaCa-2, U937, MCF-7, A549, and WiDr, with a mean IC50 value of 118 nM. HMN-176 is also cytotoxic to drug-resistant human and murine cell lines, including P388/CDDP, P388/VCR, K2/CDDP, and K2/VP-16, with IC50 values ranging from 143 nM–265 nM. In HeLa cells, HMN-176 (3 μM) blocks cell cycle at G2/M phase. HMN-176 (3 μM) down-regulates the expression of the multi-drug resistance gene (MDR1), due to the disturbance of NF-Y transcription factor binding to the MDR1 promoter. HMN-176 (250 nM–2.5 μM) inhibits meiotic spindle assembly and aster formation of Spisula oocytes. HMN-176 (2.5 μM) also inhibits aster microtubule formation from human centrosomes.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
