G-5555 - CAS:1648863-90-4 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	G-5555
英文名称:	G-5555
别名:	G-5555;G5555
CAS No:	1648863-90-4	分子式:	C₂₅H₂₅ClN₆O₃	分子量:	492.96
CAS No:	1648863-90-4
分子式:	C₂₅H₂₅ClN₆O₃
分子量:	492.96

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G10416 G-5555 ≥98% (psaitong)

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包装规格：

5mg in glass bottle

溶解性：

溶于DMSO（≥27mg/mL）

产品描述：

一种有效 PAK1 抑制剂，对 PAK1 和 PAK2 的 Ki 值分别为 3.7 nM 和 11 nM。
G‑5555 is a potent and selective PAK1 inhibitor. G‑5555 showed excellent kinase selectivity and inhibited only eight out of the 235 kinases tested other than PAK1 with inhibition >70%: PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1. G‑5555 demonstrated in vivo PK/PD effects consistent with the observed potency and pharmacokinetic properties. G‑5555 may be a potential cancer drug candidate. The p21-activated kinases (PAKs), which belong to the sterile-20 (STE20) family of kinases, play important roles in the regulation of key cellular phenomena including cell migration, proliferation, and survival mechanisms.

保存条件：

-20℃

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