| 中文名称: | GKT137831 | ||||
|---|---|---|---|---|---|
| 英文名称: | GKT137831 | ||||
| 别名: | 2-(2-氯苯基)-4-[3-(二甲基氨基)苯基]-5-甲基-1H-吡唑并[4,3-c]吡啶-3,6(2H,5H)-二酮;2-(2-氯苯基)-4-(3-(二甲氨基)苯基)-5-甲基-1H-吡唑并[4,3-c]吡啶-3,6(2H,5H)-二酮;GKT137831 抑制剂 GKT-137831；2-(2-chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1,2-dihydro-3H-pyrazolo[4,3-c]pyridine-3,6(5H)-dione | ||||
| CAS No: | 1218942-37-0 | 分子式: | C21H19ClN4O2 | 分子量: | 394.85 |
| CAS No: | 1218942-37-0 | ||||
| 分子式: | C21H19ClN4O2 | ||||
| 分子量: | 394.85 | ||||
一种选择性的NADPH氧化酶(NOX1/4)抑制剂。
GKT137831 is a novel and potent Nox4 inhibitor. GKT137831 reduced the increased leukocyte adherence to the vasculature, the pro-inflammatory phenotype of microglia and macroglia, the increased gene and protein expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and leukocyte adhesion molecules as well as vascular leakage. In all cultured cell types, GKT137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators. GKT137831 may be potentially useful as a treatment for a variety of vision-threatening retinopathies.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
