| 中文名称: | FRAX1036 | ||||
|---|---|---|---|---|---|
| 英文名称: | FRAX1036 | ||||
| 别名: | FRAX1036;FRAX-1036 | ||||
| CAS No: | 1432908-05-8 | 分子式: | C28H32ClN7O | 分子量: | 518.05 |
| CAS No: | 1432908-05-8 | ||||
| 分子式: | C28H32ClN7O | ||||
| 分子量: | 518.05 | ||||
一种 PAK 抑制剂，对 PAK1，PAK2 和 PAK4 的 Ki 值分别为 23.3 nM，72.4 nM 和 2.4 μM。
FRAX1036 is a potent and selective PAK1 inhibitor. Administration of docetaxel with either FRAX1036, or PAK1 small interfering RNA oligonucleotides dramatically altered signaling to cytoskeletal-associated proteins, such as stathmin, and induced microtubule disorganization and cellular apoptosis. Live-cell imaging revealed that the duration of mitotic arrest mediated by docetaxel was significantly reduced in the presence of FRAX1036, and this was associated with increased kinetics of apoptosis.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
