中文名称: DMP 696
英文名称: DMP 696
CAS No: 202578-52-7
分子式: C18H21Cl2N5O2
分子量: 410.3
D11587 DMP 696 ≥98% (普西唐-psaitong)
包装规格:
5mg 10mg in glass bottle
产品描述:

基本信息

产品编号:

D11587

产品名称:

DMP 696

CAS:

202578-52-7

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C18H21Cl2N5O2

溶于液体

-80℃

六个月

分子量

410.30

-20℃

一个月

化学名: 

8-(2,4-Dichlorophenyl)-N-(1,3-dimethoxypropan-2-yl)-2,7-dimethylpyrazolo[5,1-f][1,3,5]triazin-4-amine

 

生物活性

产品描述

一种促肾上腺素皮质激素释放激素受体1 (CRHR1) 拮抗剂,常用于焦虑和抑郁症的研究。

体内研究

DMP696 (3mg/kg, p.o.) attenuates consolidation of remote fear memories of mice, without affecting their expression and retention. WT mice treated with DMP696 for 1 week starting 24 h after foot shock also show reduced synaptosomal GluR1 levels than do shocked vehicle-treated controls[1]. Rats treated with different doses of DMP696 (1, 3, 10, 30mg/kg) show very little freezing during the 2-minute preshock interval. Rats treated with DMP696 exhibit a significant overall reduction in CREB phosphorylation, in both the LA, and BLA, but not in the CeA. DMP696 treatment reduces levels of LA and BLA pCREB across all time intervals that do not differ significantly from homecage pCREB levels (P>0.05). In the CeA, both vehicle- and DMP696- treated rats exhibit significantly higher pCREB expression at each post-conditioning time interval than homecage pCREB levels. Rats in the 30 ng DMP696 group exhibit significantly less freezing in comparison to vehicle-treated animals

 

推荐实验方法(仅供参考)

Animal Administration

DMP696 is dissolved in saccharose-flavored NaCl 0.9% containing 10% DMSO, 10% PEG 400, and Tween-80 (1 drop/mL). Drug suspension is delivered on an oat flake and then fed to animals at a final dose of 3mg/kg. Controls receive an oat flake soaked with saccharose-flavored vehicle only. The dose of 3mg/kg is chosen on the basis of pilot experiments in which doses of 3, 10, and 30mg/kg have been compared. The drug solutions are always freshly pipetted onto the flake and shortly dried before delivery. Ad libitum-fed mice receive some saccharose-flavored oat flakes 2 days before starting an experiment to habituate them to the novel food. Over the course of treatment, mice show no signs of aversion against the drug-soaked flakes, but readily ate them within a few seconds after delivery.

保存条件:
-20℃
UN码:
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

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用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

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    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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    C6=C5/X C6: LOG(C6):
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    C8=C7/X C8: LOG(C8):