| 中文名称: | C-178 | ||||
|---|---|---|---|---|---|
| 英文名称: | C-178 | ||||
| 别名: | C178；N-(Dibenzo[b,d]furan-3-yl)-5-nitrofuran-2-carboxamide； N-Dibenzofuran-3-yl-5-nitrofuran-2-carboxamide； N-3-Dibenzofuranyl-5-nitro-2-furancarboxamide；2-Furancarboxamide,N-3-dibenzofuranyl-5-nitro-;STING inhibitor C-178 | ||||
| CAS No: | 329198-87-0 | 分子式: | C17H10N2O5 | 分子量: | 322.27 |
| CAS No: | 329198-87-0 | ||||
| 分子式: | C17H10N2O5 | ||||
| 分子量: | 322.27 | ||||
包装规格：
2mg 5mg 10mg 25mg 50mg 100mg in glass bottle
产品简介：
C-178 是 STING 的有效和选择性共价抑制剂。C-178 与 Cys91 结合，并抑制小鼠中而非人中由不同的激活剂引起的 STING 反应。
溶解性：
溶于DMSO （41.67 mg/mL）
储备液保存：
-80°C, 2 years
-20°C, 1 year
-20°C, 1 year
靶点：
STING
体外研究：
C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells.
C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1.
C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.
C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts.
C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1.
C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.
C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts.
保存条件：
-20°C
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
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安全说明：
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参考文献 & 客户发表文献
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摩尔浓度计算公式
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开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
