| 中文名称: | CP-532623 | ||||
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| 英文名称: | CP-532623 | ||||
| 别名: | (2R,4S)-4-[Acetyl[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid 1-methylethyl ester | ||||
| CAS No: | 261947-38-0 | 分子式: | C27H27F9N2O3 | 分子量: | 598.5 |
| CAS No: | 261947-38-0 | ||||
| 分子式: | C27H27F9N2O3 | ||||
| 分子量: | 598.5 | ||||
基本信息
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产品编号： |
C70135 |
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产品名称： |
CP-532623 |
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CAS: |
261947-38-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
598.50 |
-20℃ |
一个月 |
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化学名： |
(2R,4S)-4-[Acetyl[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-1(2H)-quinolinecarboxylic acid 1-methylethyl ester |
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生物活性
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产品描述 |
CETP抑制剂，可提高高密度脂蛋白胆固醇水平。CP-532623与Torcetrapib的结构相似，并具有高度亲脂性。 |
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靶点 |
CETP |
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体外研究 |
CP-532623 is highly lymphatically transported (28% of dose), and lymphatic transport is closely correlated with drug affinity for ex-vivo lymph lipoproteins or triglyceride emulsions and poorly relates to solubility in mixtures of lipoprotein core and/or surface lipids. CP-532623 alters the kinetics of lymph lipid transport and decreases lymph lipid transport in chylomicrons |
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体内研究 |
CP-532623 (50mg; oral administration; adult male greyhound dogs) treatment substantially transports into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhances oral bioavailability (from 44 to 58%, respectively) and the proportion of the absorbed dose transports via the lymph (from 61 to 86% and from 68 to 83%, respectively). Lymphatic triglyceride transport is significantly lower in fed dogs administered CP-532623 |
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Animal Model: |
Adult male greyhound dogs (27-39kg) |
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Dosage: |
50mg |
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Administration: |
Oral administration with a long-chain lipid formulation to fed lymphcannulated |
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Result: |
Substantially transported into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhanced oral bioavailability and the proportion of the absorbed dose transported via the lymph. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
