| 中文名称: | CTAP | ||||
|---|---|---|---|---|---|
| 英文名称: | CTAP | ||||
| 别名: | CTAP (4R,7S,10S,13R,16S,19R)-N-[(2S,3R)-1-Amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-10-[3-(diaminomethylideneamino)propyl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide | ||||
| CAS No: | 103429-32-9 | 分子式: | C51H69N13O11S2 | 分子量: | 1104.3 |
| CAS No: | 103429-32-9 | ||||
| 分子式: | C51H69N13O11S2 | ||||
| 分子量: | 1104.3 | ||||
包装规格：
1mg 5mg in glass bottle
产品简介：
一种强效、高选择性的脑渗透类阿片受体 (μ opioid receptor）拮抗剂 (IC50=3.5 nM)，对 δ opioid受体 (IC50=4500 nM) 和生长抑素受体具有超过 1200 倍的选择性。CTAP 可用于 L -多巴胺诱导的运动障碍 (LID) 的研究。
CTAP is a selective μ opioid receptor antagonist that displays selectivity over δ opioid and somatostatin receptors. CTAP is brain penetrant and active in vivo.
CTAP is a selective μ opioid receptor antagonist that displays selectivity over δ opioid and somatostatin receptors. CTAP is brain penetrant and active in vivo.
靶点：
μ Opioid Receptor/MOR:3.5 nM (IC50);δ Opioid Receptor/DOR:4500 nM (IC50)
体内研究：
CTAP (0-1 mg/kg, IP, single) blocks morphine’s antinociceptive effect.
CTAP (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements.
CTAP is stable in the blood and serum of rats (T1/2 > 500 min), showing that the structure of this peptide offers enzymatic resistance.
CTAP is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%).
CTAP (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements.
CTAP is stable in the blood and serum of rats (T1/2 > 500 min), showing that the structure of this peptide offers enzymatic resistance.
CTAP is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%).
保存条件：
-20℃
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
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