Cefetrizole - CAS:65307-12-2 - CAS号查询_生物试剂_化学试剂_分析试剂

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C11216 Cefetrizole (psaitong)

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包装规格：

1mg in glass bottle

产品描述：

基本信息

产品编号：	C11216
产品名称：	Cefetrizole
CAS:	65307-12-2	储存条件	粉末	-20℃	四年

分子式：	C16H15N5O4S3		溶于液体
分子量	437.52
化学名：	(6R,7R)-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-3-(1H-1,2,4-triazol-5-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

生物活性

产品描述	一种α-Glucosidase抑制剂
靶点	IC50: 2.1μM (α-Glucosidase) Ki: 0.578μM (α-Glucosidase)
体外研究	In in vitro α-Glucosidase assays, Ceftezole is shown to be a reversible, non-competitive inhibitor of yeast α-glucosidase with a Ki value of 5.78×10^-7 M when the enzyme mixture is pretreated with ceftezole
体内研究	Using an in vivo streptozotocin-induced mouse model, blood glucose levels are confirmed to be decreased by 30% 20 min after Ceftezole treatment (10mg/kg/day). Expression levels of glycogen synthase kinase-3, peroxisome proliferatoractivated receptor-γ, and uncoupling protein-3 mRNA are also slightly decreased compare to controls following Ceftezole treatment

推荐实验方法(仅供参考)

Kinase Assay	Ceftezole at the designated concentrations is added to the enzyme buffer solution and incubated at 30˚C for 1 h, and the substrate is then added to start the enzyme reaction. When pretreatment is not specified, mixtures of substrate and Ceftezole at various concentrations are prepared beforehand and added to the enzyme solution. Enzyme reactions are performed at 30˚C for 30 min, and 3 vol of 1 M sodium carbonate are then added to stop the reaction. The total reaction volume is 100μL. Enzymatic activity is quantified by measuring the absorbency at 405nm

Animal Administration	Diabetes is induced by intravenous STZ injections [30mg/kg in fresh 10mM sodium citrate buffer (pH 4.5)] into veins of mice in one diabetic control group and one treatment group. Diabetic female mice are identified as those having blood glucose levels >250mg/dL using a kit. Ceftezole or vehicle (distilled water) is given intraperitoneally (30mg/kg/day) every day for 14 days. Twenty-four hours after the final Ceftezole treatment, mice are anesthetized with pure diethylether inhalation, and blood analysis is carried out

保存条件：

-20℃

UN码：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )