| 中文名称: | CRF(6-33)(human) TFA | ||||
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| 英文名称: | CRF(6-33)(human) TFA | ||||
| CAS No: | 分子式: | C143H232F3N41O45S | 分子量: | 3334.68 | |
| CAS No: | |||||
| 分子式: | C143H232F3N41O45S | ||||
| 分子量: | 3334.68 | ||||
基本信息
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产品编号： |
C111011 |
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产品名称： |
CRF(6-33)(human) TFA |
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CAS: |
195055-03-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
3334.68 |
-20℃ |
1个月 |
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化学名： |
3-(6-(Dimethylamino)-4-methylpyridin-3-yl)-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.6279mL |
13.1396mL |
26.2791mL |
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5mM |
0.5256mL |
2.6279mL |
5.2558mL |
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10mM |
0.2628mL |
1.3140mL |
2.6279mL |
生物活性
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产品描述 |
一种 CRF 结合蛋白配体 (CRF-BP) 抑制剂，与 CRF-BP 竞争性结合，但不与突触后 CRF 受体结合。CRF(6-33)(human) TFA 具有抗肥胖作用。 |
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靶点 |
Ki:2 to 5nM (CRF1) |
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体外研究 |
R121919 is a potent small-molecule CRF1 receptor antagonistwith high affinity for the CRF1 receptor (Ki=2–5nM) and over 1000-fold weaker activity at the CRF2 receptor,CRF-binding protein,or 70 other receptor types. |
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体内研究 |
R121919 dose dependently decreases adrenocorticopin hormone and corticosterone responses to restraint stress in rats.Peak plasma adrenocorticopin hormone and corticosterone concentrations at a dose of 10mg/kg R121919 are 9 and 25%,respectively.R121919 reduces levels of anxiety in mice with a steep dose-response curve.Molecules such as GR,MR,BAG-1 and AP-1 have been identified as some of the drug's intracellular targets. |
推荐实验方法(仅供参考)
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动物实验: |
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Rats:For the restraint stress,R121919 is dissolved in an aqueous 70% (v/v) polyethylene glycol 400 solution,and serially diluted in this vehicle to the appropriate concentrations.The drug is injected i.v.in a volume of 1mL/kg to Male SpragueDawley rats.For the defensive withdrawal experiments,R121919 solutions are made fresh the night before each experiment.R121919 is dissolved in a vehicle consisting of 5% (v/v) polyethoxylated castor oil. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
