| 中文名称: | BRD7389 | ||||
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| 英文名称: | BRD7389 | ||||
| 别名: | BRD7389 2-hydroxy-1-(phenethylamino)-7H-naphtho[1,2,3-de]quinolin-7-one | ||||
| CAS No: | 376382-11-5 | 分子式: | C24H18N2O2 | 分子量: | 366.41 |
| CAS No: | 376382-11-5 | ||||
| 分子式: | C24H18N2O2 | ||||
| 分子量: | 366.41 | ||||
基本信息
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产品编号： |
B11309 |
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产品名称： |
BRD7389 |
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CAS: |
376382-11-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
366.41 |
-20℃ |
一个月 |
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化学名： |
2-hydroxy-1-(phenethylamino)-7H-naphtho[1,2,3-de]quinolin-7-one |
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生物活性
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产品描述 |
一种特异性的RSK家族激酶抑制剂,可以诱导胰腺α细胞中胰岛素表达。 |
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靶点 |
RSK1 1.5μM(IC50) |
RSK2 2.4μM(IC50) |
RSK3 1.2μM(IC50) |
CDK5/p35 6.5μM(IC50) |
DRAK1 2.8μM(IC50) |
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FLT3 3.5μM(IC50) |
PIM1 3.7μM(IC50) |
PKG1α 6.5μM(IC50) |
SGK 13.8μM(IC50) |
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体外研究 |
BRD7389 (0.425-6.8μM) induces insulin expression in mouse α-cells after 3 days treatment. BRD7389 induces a dosedependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85μM; 5 days treatment with BRD7389 results in greater induction of insulin gene expression, about 50-fold at 0.85μM. BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line. BRD7389 also increases β-cell-specific gene expression in primary human islet cells. BRD7389 (1μM; added 30 min prior to Carbachol treatment 48 h) fully abolishes carbachols timulated cell proliferation, but has little effect on the basal level of proliferation RT-PCR |
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Cell Line: |
Mouse α-cell line |
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Concentration: |
0.425, 0.85, 1.7, 3.4, 6.8μM |
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Incubation Time: |
3 days and 5 days |
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Result: |
Up-regulated expression of Pdx1. |
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Cell Proliferation Assay |
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Cell Line: |
SNU-407 colon cancer cell |
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Concentration: |
1μM |
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Incubation Time: |
Added 30 min prior to Carbachol treatment (48 h) |
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Result: |
Almost completely blocked Carbachol (1mM)-stimulated cell proliferation. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
