| 中文名称: | 360A iodide | ||||
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| 英文名称: | 360A iodide | ||||
| 别名: | 360 A 碘化物 360 A iodide | ||||
| CAS No: | 737763-37-0 | 分子式: | C??H??I?N?O? | 分子量: | 703.31 |
| CAS No: | 737763-37-0 | ||||
| 分子式: | C??H??I?N?O? | ||||
| 分子量: | 703.31 | ||||
基本信息
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产品编号： |
A11380 |
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产品名称： |
360A iodide |
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CAS: |
737763-37-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
703.31 |
-20℃ |
一个月 |
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化学名： |
2-N,6-N-bis(1-methylquinolin-1-ium-3-yl)pyridine-2,6-dicarboxamide;diiodide |
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Solubility (25°C)： |
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体外:
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DMSO |
2mg/mL(2.84mM;Need ultrasonic) |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.4218mL |
7.1092mL |
14.2185mL |
生物活性
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产品描述 |
一种 G-四联体 (G-quadruplex) 的稳定剂，同时可抑制端粒酶 (telomerase) 的活性，在 TRAP-G4 实验中，IC50 值为 300nM。 |
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靶点 |
IC50: 300nM (Telomerase) G-quadruplex |
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体外研究 |
360A iodide inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1μM, 3.9 ± 0.4μM, 8.4 ± 0.5μM, >15μM and 17.4 ± 1.2μM, respectively[1]. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions |
推荐实验方法(仅供参考)
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Cell Assay |
The cell proliferation reagent WST-1 assay is performed. In brief, cells are seeded at various densities, depending on cell type (0.25-4 × 103 cells/well in 100μL complete medium), in 96-well culture plates and treated with various concentrations (0.1- 20μM) of 360A or the corresponding concentrations of DMSO (control wells) for 3 or 7 days at 37°C in an atmosphere containing 5% CO2. For 7-day assays, the medium is changed on day 3. Experiments are performed in triplicate. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
