唑来磷酸一水化合物 - CAS:165800-06-6 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	唑来磷酸一水化合物促销
英文名称:	Zoledronic acid monohydrate
别名:	唑来磷酸一水化合物 P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate
CAS No:	165800-06-6	分子式:	C₅H₁₀N₂O₇P₂^.H₂O	分子量:	290.1
CAS No:	165800-06-6
分子式:	C₅H₁₀N₂O₇P₂^.H₂O
分子量:	290.1
MDL:	MFCD08448695

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Z10002 唑来磷酸一水化合物 ≥98%(HPLC) (psaitong)

相关产品

包装规格：

1g 5g 25g in glass bottle

溶解性：

溶于水（ ≥2mg/mL ）

产品描述：

基本信息

产品编号：Z10002
产品名称：Zoledronic acid monohydrate
CAS:	165800-06-6	储存条件	粉末	2-8℃	四年

分子式：	C5H10N2O7P2.H2O		溶于液体	-80℃	两年
分子量	290.10			-20℃	一个月
化学名：	(1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid hydrate
Solubility (25°C)	体外	DMSO	0.01mg/mL (0.03mM)
		Ethanol	Insoluble
		Water	Insoluble
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	3.4471mL	17.2354mL	34.4709mL
5mM	0.6894mL	3.4471mL	6.8942mL
10mM	0.3447mL	1.7235mL	3.4471mL

生物活性

产品描述	一种高活性的双膦酸盐和PKC激活剂。
靶点/IC₅₀	Ras ()	Rho ()
体外研究	Zoledronic Acid monohydrate (0.1-1 µM; 48 hours) increases receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells. Zoledronic Acid monohydrate increases the expression of osteoclastogenesis supporting factor from MLO-Y4 cells. Zoledronic Acid monohydrate enhances the RANKL expression via IL-6/ JAK2/STAT3 pathway in MLO-Y4 cells. Zoledronic Acid monohydrate inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways. Zoledronic Acid monohydrate (10-100µM; 1-7 days) markedly reduces the viability of MC3T3-E1 cells. Zoledronic Acid monohydrate (10-100µM; 1-7 days) induces apoptosis in MC3T3-E1 cells. Zoledronic Acid monohydrate (10-100µM; 4 days) inhibits cell viability due to the induction of apoptosis. Zoledronic Acid monohydrate exerts inhibitory effects on the differentiation and maturation of MC3T3-E1 cells at concentrations <1µM. Cell Viability Assay
	Cell Line:	MC3T3-E1 cells
	Concentration:	0.02µM , 0.1µM, 1µM, 10µM, 100µM
	Incubation Time:	1day, 3days, 5days, 7days
	Result:	Reduced cells viability at 10µM and 100µM.
	Apoptosis Analysis
	Cell Line:	MC3T3-E1 cells
	Concentration:	0.02µM , 0.1µM, 1µM, 10µM, 100µM
	Incubation Time:	1days, 4days, 7days
	Result:	Increased the number of early apoptotic cells and late apoptotic or necrotic cells at dosedependent and time-dependent (high concentrations).
	Western Blot Analysis
	Cell Line:	MC3T3-E1 cells
	Concentration:	0.02µM , 0.1µM, 1µM, 10µM, 100µM
	Incubation Time:	4days
	Result:	Down-regulated the protein level of inactive caspase-3 and up-regulated the protein level of active caspase-3 at the concentrations of 10 and 100µM.
体内研究	Zoledronic Acid monohydrate (0.05mg/kg; i.p.; weekly; for 3weeks) increases bone mineral density and content. Zoledronic Acid monohydrate (0.5-1mg/kg; i.p.; weekly; for 3weeks) inhibits both osteoclast and osteoblasts function and bone remodeling in vivo interfering with bone mechanical properties.
	Animal Model:	Five-week-old C57BL6 mice
	Dosage:	0.05mg/kg, 0.5mg/kg, 1mg/kg
	Administration:	Intraperitoneal injection, weekly, for 3weeks
	Result:	Intraperitoneal injection, weekly, for 3weeks.