YL0919 - CAS:1339058-04-6 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	YL0919 促销
英文名称:	YL0919
别名:	1-[[4-羟基-1-(苯基甲基)-4-哌啶基]甲基]-2(1H)-吡啶酮盐酸盐 YL-0919
CAS No:	1339058-04-6	分子式:	C₁₈H₂₃ClN₂O₂	分子量:	334.84
CAS No:	1339058-04-6
分子式:	C₁₈H₂₃ClN₂O₂
分子量:	334.84

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Y10005 YL0919 ≥98% (HPLC) (psaitong)

相关产品

包装规格：

2mg 5mg 25mg 100mg in glass bottle

溶解性：

溶于DMSO(≥ 30 mg/mL)

产品描述：

基本信息

产品编号：	Y10005
产品名称：	YL0919
CAS:	1339058-04-6	储存条件	粉末	-20℃	四年

分子式：	C18H23ClN2O2		溶于液体	-80℃	6个月
分子量	334.84			-20℃	1个月
化学名：	1-[(1-Benzyl-4-hydroxy-4-piperidinyl)methyl]-2(1H)-pyridinone hydrochloride (1:1)
Solubility (25°C)：
体外:	DMSO	≥ 30 mg/mL (89.60mM)
	Ethanol
	Water
体内(现配现用):	1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80 →45% saline Solubility: ≥ 2.5 mg/mL (7.47mM); Clear solution
	此⽅案可获得 ≥ 2.5 mg/mL (7.47mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50μL Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。
	2.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (7.47mM); Clear solution
	此⽅案可获得 ≥ 2.5 mg/mL (7.47mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。
	3.请依序添加每种溶剂:10% DMSO→90% corn oil Solubility: ≥ 2.5 mg/mL (7.47mM); Clear solution
	此⽅案可获得 ≥ 2.5 mg/mL (7.47mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。以 1mL ⼯作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900μL ⽟⽶油中，混合均匀。
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.9865mL	14.9325mL	29.8650mL
5mM	0.5973mL	2.9865mL	5.9730mL
10mM	0.2987mL	1.4933mL	2.9865mL

生物活性

产品描述	一种新型的抗抑郁药物,是5-HT1A受体激动剂，也是血管收缩素的选择性再摄取抑制剂。
靶点	5-HT1A Receptor
体外研究	Hypidone hydrochloride inhibits the uptake of [3H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells stably expressing hSERT with IC50 values of 1.78nM and 1.93,respectively. Hypidone hydrochloride (0.01 nM-10μM) concentration-dependently inhibits forskolin-stimulated cAMP formation, exerts a concentration-dependent inhibitory effect on cAMP formation with an IC50 of approximately 23.9nM. And in antagonism studies, WAY-100635 prevents Hypidone hydrochloride-mediated inhibition of forskolin-stimulated cAMP formation. Hypidone hydrochloride shows affinities to rat 5-HT1A receptors, SERTs, NETs, and DATs, it binds to 5-HT1A receptor, serotonin transporter (SERT) with high affinity (Ki=0.19 and 0.72nM, respectively), but its affinity to NET and DAT are low, blocking [3H]nisoxetine and [3H]win35428 binding with Ki values of 650nM and 2652nM respectively.
体内研究	Hypidone hydrochloride (YL0919) (oral administration; 1.25 or 5 mg/kg; 4 weeks) and fluoxetine (10 mg/kg) reverses the inhibition of locomotor activity in CUS rats. Hypidone hydrochloride (oral administration; 1.25, 2.5, and 5 mg/kg; 4 weeks) significantly reduces the immobility time in TST in mcie FST in mice. Besides, Hypidone hydrochloride displays no effect on the locomotor activity in a separate OFT. Furthermore, the antidepressant-like effect of Hypidone hydrochloride in TST and FST is completely bunted by coadministration with WAY-100635 .
	Animal Model:	Male ICR mice weighing 18–22 g
	Dosage:	1.25, 2.5, and 5 mg/kg
	Administration:	Oral administration
	Result:	Had an effect on Antidepressant-like mice in TST and FST.