盐酸维拉帕米 - CAS:152-11-4 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	盐酸维拉帕米促销
英文名称:	(±)-Verapamil hydrochloride
别名:	盐酸维拉帕米 ±)-Verapamil hydrochloride
CAS No:	152-11-4	分子式:	C₂₇H₃₈N₂O₄^.HCl	分子量:	491.06
CAS No:	152-11-4
分子式:	C₂₇H₃₈N₂O₄^.HCl
分子量:	491.06
MDL:	MFCD00055208	EINEC:	205-800-5
EINEC:	205-800-5

安全技术说明书(PDF) MSDS(PDF) 点击下载技术规格说明书(PDF) 点击下载产品说明书(PDF)

V60001 盐酸维拉帕米 ≥99% (psaitong)

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熔点：

142°C

外观与性状：

白色粉末

包装规格：

1g 5g 25g 100g in poly bottle

溶解性：

溶于甲醇（50mg/mL)

产品描述：

基本信息

产品编号：	V60001
产品名称：	(±)-Verapamil hydrochloride
CAS:	152-11-4	储存条件	粉末	室温	四年
分子式：	C27H38N2O4.HCl		溶于液体	-80℃(避光)	6个月
分子量：	491.06			-20℃(避光)	1个月
化学名：	Benzeneacetonitrile,alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-,monohydrochloride,(+-)-
Solubility (25°C)：
体外:	DMSO	98mg/mL (199.56mM)
	Ethanol	12mg/mL (24.43mM)
	Water	50mg/mL (101.82mM)
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.0364mL	10.1821mL	20.3641mL
5mM	0.4073mL	2.0364mL	4.0728mL
10mM	0.2036mL	1.0182mL	2.0364mL
50mM	0.0407mL	0.2036mL	0.4073mL

生物活性

产品描述	α肾上腺素受体拮抗剂，L型钙通道阻滞剂。
靶点	Calcium channel Permeability-glycoprotein (P-gp) CYP3A4
体外研究	The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs,and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0μM.
体内研究	Given orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia,and also in modulating the atrioventricular nodal response in atrial fibrillation.Verapamil is injected i.v.into a femoral vein prior to ischemia.Verapamil (1mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC),ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion.Total arrhythmia scores are significantly increased when the heart is subjected to ischemia.Verapamil (1mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia.

推荐实验方法(仅供参考)

细胞实验:
Cells (1×105) are treated with 10nM Bortezomib and/or 70µM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue.Activity of the mitochondrial dehydrogenase results in conversion of the coloring,which is followed by measurement of the absorption using a spectrophotometer.

动物实验:

Rats

Adult male Sprague-Dawley (SD) rats (250−350g) are used.Verapamil (1mg/kg) is injected i.v.into a femoral vein 10 min prior to ischemia.A sham group undergoes the same surgical procedures,except the suture underneath the LAD is left untied.In another series of experiment,arrhythmia is induced by Bay K8644,an L-type calcium channel agonist,at a dose of 0.1mg/kg given i.v.into the FV.Verapamil (1mg/kg) is administered 10 min prior to Bay K8644.All injections are performed within 30 sec.

保存条件：

室温

UN码：

HazardClass：

危害声明：

安全说明：

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