| 中文名称: | TCS PIM-1 1 促销 | ||||
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| 英文名称: | TCS PIM-1 1 | ||||
| 别名: | 6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile | ||||
| CAS No: | 491871-58-0 | 分子式: | C18H11BrN2O2 | 分子量: | 367.2 |
| CAS No: | 491871-58-0 | ||||
| 分子式: | C18H11BrN2O2 | ||||
| 分子量: | 367.2 | ||||
| MDL: | MFCD00276275 | ||||
基本信息
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产品编号： |
T10027 |
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产品名称： |
TCS PIM-1 1 |
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CAS: |
491871-58-0 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
367.20 |
-20℃ |
1个月 |
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化学名： |
6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dihydropyridine-3-carbonitrile |
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Solubility (25°C)： |
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体外:
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DMSO |
35mg/mL (95.31mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.7233mL |
13.6166mL |
27.2331mL |
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5mM |
0.5447mL |
2.7233mL |
5.4466mL |
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10mM |
0.2723mL |
1.3617mL |
2.7233mL |
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50mM |
0.0545mL |
0.2723mL |
0.5447mL |
生物活性
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产品描述 |
一种ATP竞争性PIM-1激酶抑制剂。 |
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靶点 |
Pim1 |
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50nM |
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体外研究 |
TCS PIM-1 1 (compound 1),a substituted pyridone scaffold,binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism.Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2.Hence,small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors.TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
