| 中文名称: | SAR407899 free base 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | SAR407899 free base | ||||
| 别名: | 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one SAR407899 | ||||
| CAS No: | 923359-38-0 | 分子式: | C14H16N2O2 | 分子量: | 244.29 |
| CAS No: | 923359-38-0 | ||||
| 分子式: | C14H16N2O2 | ||||
| 分子量: | 244.29 | ||||
一种具有选择性和抗高血压活性的Rho激酶抑制剂。
SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. SAR407899 is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM, respectively. SAR407899 is approximately 8-fold more active than fasudil. SAR407899 potently (mean IC(50) values: 122 to 280 nM) and species-independently relaxed precontracted isolated arteries of different species and different vascular beds. The antihypertensive effect of SAR407899 was superior to that of fasudil and Y-27632.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
